Antifungals and antiparasitics
Azoles, amphotericin and terbinafine for fungi; artemisinins and chloroquine for malaria; and drugs for worms. 14 drugs in 8 classes. Read them through, then practice: their classes, how they work, what they treat and what they're known for. 16 questions, about 5 minutes.
Free, and no account needed.
In this group
The classes and their drugs
- Azole antifungalsInhibiting the fungal P450 enzyme that makes ergosterol for the cell membrane
- FluconazoleItraconazoleClotrimazole
- Polyene antifungalsBinding ergosterol and forming pores that make the fungal membrane leak
- Amphotericin BNystatin
- AllylaminesInhibiting squalene epoxidase, so toxic squalene builds up in the fungus
- Terbinafine
- ArtemisininsReleasing free radicals when heme iron splits their peroxide bridge
- ArtemetherArtesunate
- 4-aminoquinolinesBlocking the parasite from turning toxic heme into harmless crystals
- ChloroquineHydroxychloroquine
- 8-aminoquinolinesKilling dormant liver forms (hypnozoites) through oxidizing metabolites
- Primaquine
- Benzimidazole anthelminticsBinding worm β-tubulin so microtubules cannot form and glucose uptake fails
- AlbendazoleMebendazole
- AvermectinsOpening glutamate-gated chloride channels, paralyzing the parasite
- Ivermectin