Skip to main content
Life Science Dictionary

Prokaryote

Cell Biology · Microbiology

Say it: proh-KAR-ee-oht

A prokaryote is a usually single-celled organism, a bacterium or an archaeon, whose cell has no nucleus or other membrane-bound organelles.

Also: prokaryotes, procaryote, prokaryotic cell

Definition

What is a prokaryote?

A prokaryote is an organism whose cell lacks a nucleus. Its DNA, usually a single circular chromosome, lies in a region of the cytoplasm called the nucleoid, with no membrane around it. Prokaryotes make up two of the three domains of life, Bacteria and Archaea, and almost all of them live as single cells.

Like every cell, a prokaryote has a plasma membrane, cytoplasm, DNA and ribosomes, but its ribosomes (70S) are smaller than those in the eukaryotic cytoplasm (80S). Most have a cell wall outside the membrane; in bacteria the wall is built from peptidoglycan, a polymer that archaea lack. Many also carry plasmids, small extra circles of DNA that can hold genes such as those for antibiotic resistance, along with flagella for swimming and hair-like pili or fimbriae for sticking to surfaces or passing DNA to other cells.

Prokaryotic cells are typically much smaller than eukaryotic cells, often only one to a few micrometers across. That small size gives them a large surface area for their volume, so nutrients and wastes can spread through the cell by diffusion alone.

Word parts

Where does the word “prokaryote” come from?

pro-
beforeGreek pro
kary-
nut, kernel (here, the nucleus)Greek karyon

Practice it

Where you'll meet it

Related

Sources

Checked against

Written for biofideX in plain words, after checking these references:

Last updated

Spotted a mistake? Tell us and we'll correct it.

Keep going

Practice Cell Biology

Free cell biology quizzes, with an explanation for every answer.

See the Quizzes