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Life Science Dictionary

Cell membrane

Cell Biology · Biochemistry

Say it: SEL MEM-brayn

The cell membrane is the thin, flexible boundary of lipids and proteins that encloses every cell and controls what enters and leaves it.

Also: plasma membrane, plasmalemma, cytoplasmic membrane, cell membranes

Definition

What is the cell membrane?

The cell membrane, or plasma membrane, is the outer boundary of every cell, separating the cytoplasm from the fluid around it. Its basic structure is a phospholipid bilayer: two sheets of phospholipid molecules with their water-attracting phosphate heads facing outward and their water-repelling fatty acid tails tucked inside. In animal cells, cholesterol sits among the phospholipids and helps keep the membrane fluid over a range of temperatures.

Proteins are embedded in or attached to the bilayer, and many carry sugar chains on the outer surface. The fluid mosaic model, proposed by Singer and Nicolson in 1972, describes this arrangement as a moving patchwork of lipids and proteins rather than a rigid sheet. Because its oily core blocks ions and most polar molecules, the membrane is selectively permeable: small nonpolar molecules cross it directly, while other substances need channels, carriers, pumps or vesicles.

Membrane proteins also serve as receptors for hormones and other signals, and surface sugar-protein complexes let cells recognize one another. Plants, fungi and most bacteria have a tougher cell wall outside the membrane, but the membrane is what controls exchange.

Word parts

Where does the term “cell membrane” come from?

cell
small roomLatin cella
membrane
thin skin, parchmentLatin membrana

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